CAS# 87616-84-0
Also Known As SKF-110679
Sequence His-D-Trp-Ala-Trp-D-Phe-Lys-NH₂
Class Synthetic Peptide
Form Lyophilized Powder
Receptor Target
Research Pathway
Research Model
GHRP-6 (Growth Hormone Releasing Peptide-6; SKF-110679; CAS# 87616-84-0) is a synthetic hexapeptide agonist of the Growth Hormone Secretagogue Receptor type 1a (GHSR-1a), also known as the ghrelin receptor. The compound incorporates two D-amino acid substitutions (D-Trp² and D-Phe⁵) that confer resistance to proteolytic degradation while maintaining high receptor affinity. GHRP-6 is studied as a pharmacological tool for investigating GHSR-1a receptor pharmacology, ghrelin axis signalling, and growth hormone secretagogue mechanisms in in vitro research models. Supplied by NexPept as a lyophilized powder for in vitro laboratory research use. This compound has not been authorized by Health Canada for any therapeutic, clinical, or human use.
Molecular Profile
CAS#, sequence, formula, molecular weight, analytical data
CAS#, sequence, formula, molecular weight, analytical data
| Property | Value |
|---|---|
| CAS Number | 87616-84-0 |
| Also Known As | SKF-110679; U-75799E; Hexapeptide-2; [His¹,D-Trp²,Ala³,Trp⁴,D-Phe⁵,Lys⁶]-GHRP |
| Sequence | His-D-Trp-Ala-Trp-D-Phe-Lys-NH₂ (C-terminal amide) |
| D-Amino Acid Substitutions | D-Trp² and D-Phe⁵ — protease resistance and GHSR-1a binding optimisation |
| Molecular Formula | C₄₆H₅₆N₁₂O₆ |
| Molecular Weight | ~873.0 Da |
| Compound Class | Synthetic hexapeptide — GHSR-1a agonist / growth hormone secretagogue |
| Receptor Target | GHSR-1a (Ghrelin Receptor / Growth Hormone Secretagogue Receptor type 1a) |
| Physical Form | Lyophilized powder |
| Analytical Method | High-Performance Liquid Chromatography (HPLC) + Mass Spectrometry (MS) |
| Appearance | White to off-white lyophilized solid |
In Vitro Research Context
Receptor pharmacology — laboratory use only
Receptor pharmacology — laboratory use only
Ghrelin receptor — Growth Hormone Secretagogue Receptor type 1a binding and signalling studies
Endogenous ghrelin pathway interaction and receptor selectivity characterisation research
Downstream GHSR-1a second messenger signalling cascade and intracellular Ca²⁺ studies
GHRP-6 is studied in preclinical in vitro settings as a pharmacological tool for investigating GHSR-1a receptor pharmacology and ghrelin axis signalling. Research applications include receptor binding competition assays, GHSR-1a agonist potency characterisation, intracellular Ca²⁺ mobilisation and cAMP pathway studies, and comparative pharmacology with endogenous ghrelin and other synthetic GH secretagogues. The incorporation of D-Trp² and D-Phe⁵ residues makes GHRP-6 a widely used reference compound in GHS-R pharmacology research for its stability and defined receptor profile.
Available Formats
5mg — lyophilized powder
5mg — lyophilized powder
| Format | Net Quantity | Physical Form |
|---|---|---|
| GHRP-6 5mg | 5 mg / vial | Lyophilized powder |
Laboratory Storage
Controlled storage conditions for lyophilized material
Controlled storage conditions for lyophilized material
Store sealed lyophilized material under controlled laboratory conditions in accordance with validated institutional SOPs and applicable technical documentation. Protect from light and moisture. Handling conditions should be established by qualified research personnel in accordance with the specific experimental protocol.
Research Literature
Scientific references & related resources
Scientific references & related resources
PubMed — GHRP-6 / GHSR-1a Research — peer-reviewed scientific literature on this compound
Berlanga-Acosta et al. (2017) — “Synthetic Growth Hormone-Releasing Peptides (GHRPs)” — comprehensive review of GHRP pharmacology and receptor biology. Clinical Medicine Insights: Endocrinology and Diabetes
Research Peptides in Canada — sourcing and research context for Canadian laboratories
What Are Research Peptides? — peptide classification and in vitro research context
This product is supplied exclusively for in vitro laboratory and non-clinical research use by qualified research personnel. It is not authorized by Health Canada for human or veterinary use. No therapeutic, clinical, or health claims are made.
This material must not be administered to humans or animals. No dosage, preparation, reconstitution, or administration instructions are provided or implied. All handling and use must be conducted by qualified personnel in accordance with applicable institutional policies and legal requirements.
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