HPLC + MS
Independently tested for identity and purity
NP-KISS-02
Aug 6, 2026
99.34%
View Certificate of Analysis
CAS# 374675-21-5
Also Known As Kp-10 (Human)
Sequence YNWNSFGLRF-NH₂
Class Synthetic Peptide
Form Lyophilized Powder
Receptor Target
Research Pathway
Receptor Motif
Kisspeptin-10 (Kp-10, human; CAS# 374675-21-5) is a synthetic decapeptide corresponding to the C-terminal 10-residue active fragment of the KISS1 gene product (kisspeptin-54 / metastin). The C-terminal RF-amide motif (Arg-Phe-NH₂) is essential for binding and activation of the kisspeptin receptor KISS1R (GPR54), a Gαq/11-coupled Class A GPCR. Kisspeptin-10 is studied as a pharmacological tool for investigating KISS1R receptor pharmacology, hypothalamic-pituitary-gonadal (HPG) axis signalling, and GnRH pulse regulation in in vitro neuroendocrine research models. Supplied by NexPept as a lyophilized powder for in vitro laboratory research use. This compound has not been authorized by Health Canada for any therapeutic, clinical, or human use.
Molecular Profile
CAS#, sequence, formula, molecular weight, analytical data
CAS#, sequence, formula, molecular weight, analytical data
| Property | Value |
|---|---|
| CAS Number | 374675-21-5 |
| Also Known As | Kp-10 (human); Kisspeptin-10 (human); KISS1(45–54)-NH₂ |
| Parent Protein | KISS1 gene product — C-terminal decapeptide fragment of kisspeptin-54 (metastin) |
| Sequence | Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂ (YNWNSFGLRF-NH₂) |
| Key Motif | C-terminal RF-amide (Arg-Phe-NH₂) — required for KISS1R binding and activation |
| Molecular Formula | C₆₃H₈₃N₁₇O₁₃ |
| Molecular Weight | ~1302 Da |
| Compound Class | Synthetic decapeptide — KISS1R agonist / RF-amide neuropeptide |
| Receptor Target | KISS1R (GPR54) — Gαq/11-coupled Class A GPCR |
| Species Note | Human sequence (Phe¹⁰); differs from mouse/rat variant (Tyr¹⁰, CAS 478507-53-8) |
| Physical Form | Lyophilized powder |
| Analytical Method | High-Performance Liquid Chromatography (HPLC) + Mass Spectrometry (MS) |
| Appearance | White to off-white lyophilized solid |
In Vitro Research Context
Receptor pharmacology — laboratory use only
Receptor pharmacology — laboratory use only
Kisspeptin receptor — Gαq/11 GPCR; IP₃/Ca²⁺ mobilisation and ERK signalling studies
Hypothalamic-pituitary-gonadal axis and gonadotropin (LH/FSH) regulation research models
Hypothalamic kisspeptin neuron models and pulsatile GnRH secretion pathway studies
Kisspeptin-10 is studied in preclinical in vitro settings as a pharmacological tool for investigating KISS1R (GPR54) receptor pharmacology and its role in regulating the hypothalamic-pituitary-gonadal axis. Research applications include KISS1R binding and activation assays, Gαq/11-mediated IP₃/Ca²⁺ intracellular signalling studies, ERK1/2 phosphorylation analysis, GnRH neuron stimulation models, and comparative potency assays with other RF-amide neuropeptides. As the minimal bioactive fragment of kisspeptin-54, Kp-10 is widely used as a reference agonist for KISS1R receptor characterisation.
Available Formats
10mg — lyophilized powder
10mg — lyophilized powder
| Format | Net Quantity | Physical Form |
|---|---|---|
| Kisspeptin-10 10mg | 10 mg / vial | Lyophilized powder |
Laboratory Storage
Controlled storage conditions for lyophilized material
Controlled storage conditions for lyophilized material
Store sealed lyophilized material under controlled laboratory conditions in accordance with validated institutional SOPs and applicable technical documentation. Protect from light and moisture. Handling conditions should be established by qualified research personnel in accordance with the specific experimental protocol.
Research Literature
Scientific references & related resources
Scientific references & related resources
PubMed — Kisspeptin / KISS1R / GPR54 Research — peer-reviewed scientific literature on this compound
Seminara et al. (2003) — “The GPR54 Gene as a Regulator of Puberty” — foundational characterisation of KISS1R/GPR54 in HPG axis regulation. N Engl J Med. PMID 15501916
Research Peptides in Canada — sourcing and research context for Canadian laboratories
What Are Research Peptides? — peptide classification and in vitro research context
This product is supplied exclusively for in vitro laboratory and non-clinical research use by qualified research personnel. It is not authorized by Health Canada for human or veterinary use. No therapeutic, clinical, or health claims are made.
This material must not be administered to humans or animals. No dosage, preparation, reconstitution, or administration instructions are provided or implied. All handling and use must be conducted by qualified personnel in accordance with applicable institutional policies and legal requirements.
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