HPLC + MS
Independently tested for identity and purity
NP-KPV-001
Apr 16, 2026
99.64%
View Certificate of Analysis
CAS# 34702-62-0
Also Known As alpha-MSH(11–13)
Class Synthetic Tripeptide / Melanocortin Fragment
Form Lyophilized Powder
Receptor Target
Peptide Length
Molecular Weight
KPV (H-Lys-Pro-Val-OH, CAS# 34702-62-0) is a synthetic tripeptide corresponding to positions 11–13 of alpha-melanocyte-stimulating hormone (α-MSH). As the C-terminal tripeptide fragment of α-MSH, KPV is studied in preclinical research for its activity at melanocortin receptors — particularly MC1R — and for its involvement in intracellular signalling pathway models including NF-κB. Supplied by NexPept as a lyophilized powder for in vitro laboratory research use. This compound has not been authorized by Health Canada for any therapeutic, clinical, or human use.
Molecular Profile
CAS#, sequence, molecular weight, analytical data
CAS#, sequence, molecular weight, analytical data
| Property | Value |
|---|---|
| CAS Number | 34702-62-0 |
| Research Designation | alpha-MSH(11–13) |
| Full Sequence Name | H-Lys-Pro-Val-OH |
| Compound Class | Synthetic tripeptide — melanocortin receptor fragment |
| Peptide Origin | C-terminal tripeptide of alpha-melanocyte-stimulating hormone (α-MSH) |
| Sequence Length | 3 amino acids (Lysine – Proline – Valine) |
| Molecular Formula | C₁₆H₃₀N₄O₄ |
| Molecular Weight | 342.4 Da |
| Receptor Target | MC1R (Melanocortin-1 Receptor); also studied at MC3R in cellular models |
| Physical Form | Lyophilized powder |
| Analytical Method | High-Performance Liquid Chromatography (HPLC) + Mass Spectrometry (MS) |
| Appearance | White to off-white lyophilized solid |
In Vitro Research Context
Receptor pharmacology — laboratory use only
Receptor pharmacology — laboratory use only
A G protein-coupled receptor (GPCR) in the melanocortin receptor family, activated by endogenous α-MSH. KPV is studied as the minimal bioactive C-terminal fragment of α-MSH that retains MC1R binding activity in vitro. It is used in receptor binding assays, NF-κB pathway modulation studies, and melanocortin signalling cascade models. Research has also examined KPV at MC3R in select cellular model systems.
KPV is investigated in preclinical in vitro settings as the shortest α-MSH fragment that retains measurable melanocortin receptor activity. Its compact tripeptide structure makes it a tractable tool compound for studying melanocortin receptor pharmacology, structure–activity relationships within the α-MSH C-terminal sequence, and downstream signalling pathways including NF-κB modulation in cellular models. Its small size also makes it relevant in peptide permeability and intracellular delivery studies.
Research context: KPV is an investigational synthetic tripeptide studied in scientific research involving melanocortin receptor signalling and intracellular pathway models. It has not been authorized by Health Canada for human or veterinary use.
Available Formats
10mg — lyophilized powder
10mg — lyophilized powder
| Format | Net Quantity | Physical Form |
|---|---|---|
| KPV 10mg | 10 mg / vial | Lyophilized powder |
Sourced from a verified batch. Quantity for use should be determined based on your specific in vitro research protocol by qualified research personnel.
Laboratory Storage
Controlled storage conditions for lyophilized material
Controlled storage conditions for lyophilized material
Store sealed lyophilized material under controlled laboratory conditions in accordance with validated institutional SOPs and applicable technical documentation. Protect from light and moisture. As a small tripeptide, KPV may be particularly susceptible to ambient humidity — store in a desiccated environment. Handling conditions should be established by qualified research personnel in accordance with the specific experimental protocol.
Note: No preparation, reconstitution, or administration instructions are provided. This compound is supplied for in vitro laboratory research use only. All handling must be conducted by qualified personnel following institutional safety protocols.
Research Literature
Scientific references & related resources
Scientific references & related resources
KPV Research Peptide Overview — NexPept compound overview and in vitro research context
PubMed — KPV / alpha-MSH(11–13) — peer-reviewed scientific literature on this compound
Research Peptides in Canada — sourcing and research context for Canadian laboratories
What Are Research Peptides? — peptide classification and in vitro research context
This product is supplied exclusively for in vitro laboratory and non-clinical research use by qualified research personnel. It is not authorized by Health Canada for human or veterinary use. No therapeutic, clinical, or health claims are made.
This material must not be administered to humans or animals. No dosage, preparation, reconstitution, or administration instructions are provided or implied. All handling and use must be conducted by qualified personnel in accordance with applicable institutional policies and legal requirements.
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